Freeze-dried versus fresh platelet-rich plasma in acute wound healing of an animal model

REGENERATIVE MEDICINE, VOL. 14, NO. 6 | SHORT COMMUNICATION

"...a significantly increased number of myofibroblasts was demonstrated in comparison with the fresh PRP group. We also demonstrated a significantly increased percentage of blood vessels in comparison with controls in both the superficial and deep epidermis."

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REVIEW OF GOOD PLATELET-RICH PLASMAPROCEDUREIN COSMETIC DERMATOLOGY AND SURGERY 

JOURNAL OF COSMETIC MEDICINE 2019 I REVIEW ARTICLE

"...platelets are not a typical cell-based materials and they have a wide range of functional variation according to patient's condition "

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The use of platelet-rich plasma in plastic surgery: A systematic review

Journal of Plastic, Reconstructive & Aesthetic Surgery (2013) 66

"This systematic review describes a substantially beneficial effect of platelet-rich plasma for several indications, including a better wound healing rate, an increased survival rate of fat grafts and an enhancement of bone graft regeneration."

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Platelet-rich Plasma: Properties and Clinical Applications

The Journal of Lancaster General Hospital • Summer 2007 • Vol. 2 

"...PRP can be exogenously applied to soft tissues to promote wound healing and tissue sealing. In patients undergoing certain surgical procedures, perioperative use of PRP may decrease the length of hospitalization and the need for allogeneic blood products. PRP is promising biotechnology that is fueling a growing interest in tissue engineering and cellular therapeutics. "

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Freeze-Dried Human Platelet-Rich Plasma Retains Activation and Growth Factor Expression after an Eight-Week Preservation Period

Asian Spine J. 2017 Jun; 11(3): 329–336.

"In the frozen group, levels were maintained for 4 weeks but decreased significantly by 8 weeks (p <0.05). The freeze-dried group maintained baseline levels of growth factors for the entire 8-week duration.."

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